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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
19.09
Human Site:
T1592
Identified Species:
30
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
T1592
I
F
P
S
D
F
P
T
E
P
P
S
L
P
R
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1600
I
F
P
S
D
F
P
T
E
P
P
S
L
P
R
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1586
I
F
P
S
D
F
P
S
E
P
P
S
L
P
R
Dog
Lupus familis
XP_534241
2041
231068
S2008
I
F
P
S
D
F
T
S
E
P
P
S
L
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1579
I
F
P
S
D
F
T
S
E
P
P
A
L
P
R
Rat
Rattus norvegicus
P41516
1526
173202
L1498
E
R
D
F
H
V
D
L
D
D
T
V
A
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1891
D
I
F
P
S
D
F
S
S
E
P
P
S
L
P
Chicken
Gallus gallus
O42131
1627
183228
A1595
E
I
F
Q
S
G
F
A
S
E
T
A
P
K
P
Frog
Xenopus laevis
NP_001082502
1579
178601
D1551
I
I
D
F
S
D
S
D
E
M
E
N
I
V
P
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S1584
D
D
E
T
G
F
N
S
F
S
H
L
D
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
P1419
G
A
K
K
K
A
P
P
K
K
R
R
A
V
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
A1492
K
S
G
R
A
R
K
A
P
P
T
Y
D
V
D
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
E1420
K
Y
T
Y
S
E
D
E
E
S
D
G
S
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
K1445
P
Q
R
A
N
R
R
K
M
T
Y
V
L
S
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E1400
V
P
K
K
S
Y
V
E
T
L
E
L
S
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
93.3
86.6
N.A.
80
13.3
N.A.
6.6
0
13.3
6.6
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
20
N.A.
13.3
6.6
26.6
20
N.A.
13.3
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
7
7
0
14
0
0
0
14
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
14
0
34
14
14
7
7
7
7
0
14
7
20
% D
% Glu:
14
0
7
0
0
7
0
14
47
14
14
0
0
0
7
% E
% Phe:
0
34
14
14
0
40
14
0
7
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
7
7
0
0
0
0
0
7
0
7
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
40
20
0
0
0
0
0
0
0
0
0
0
7
0
7
% I
% Lys:
14
0
14
14
7
0
7
7
7
7
0
0
0
7
0
% K
% Leu:
0
0
0
0
0
0
0
7
0
7
0
14
40
7
0
% L
% Met:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
7
0
0
0
0
7
0
0
0
% N
% Pro:
7
7
34
7
0
0
27
7
7
40
40
7
7
40
20
% P
% Gln:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
7
7
0
14
7
0
0
0
7
7
0
0
40
% R
% Ser:
0
7
0
34
34
0
7
34
14
14
0
27
20
14
0
% S
% Thr:
0
0
7
7
0
0
14
14
7
7
20
0
0
0
0
% T
% Val:
7
0
0
0
0
7
7
0
0
0
0
14
0
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
0
7
0
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _